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Table 1 NASH activity scoring in control and ethanol-treated OLETF and OLET rats.

From: Binge Alcohol Consumption Aggravates Oxidative Stress and Promotes Pathogenesis of NASH from Obesity-Induced Simple Steatosis

  OLETF rats OLET rats
Parameters Control, 33 wks Ethanol, 5 d/wk Ethanol, 3 d/wk Ethanol, 2 d/wk Ethanol, 1 d/wk Control, 33 wks Ethanol, 5 d/wk Ethanol, 1 d/wk
Steatosis 1.1 ± 0.2 2.1 ± 0.3a 1.9 ± 0.3a 2.0 ± 0.4a 1.9 ± 0.3 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
Lobular inflammation 0.0 ± 0.0 1.4 ± 0.2a 1.3 ± 0.2a 1.1 ± 0.2a 0.8 ± 0.1a 0.0 ± 0.0 0.5 ± 0.1 0.0 ± 0.0
Hepatocyte ballooning 0.2 ± 0.0 2.6 ± 0.4a 2.7 ± 0.4a 2.5 ± 0.3a 2.4 ± 0.3a 0.0 ± 0.0 0.0 ± 0.0 0.0 ± 0.0
NAS (0–9) 1.3 ± 0.2 6.1 ± 0.9a 5.9 ± 0.9a 5.6 ± 0.9a 5.1 ± 0.7a 0.0 ± 0.0 0.5 ± 0.1 0.0 ± 0.0
  1. Data are means ± SD of eight rats per group. Scores for steatosis (score 0–3), lobular inflammation (score 0–3) and hepatocyte ballooning (score 0–3) were summed to produce the NAS, thus ranging from 0 to 9.
  2. aP < 0.001 versus OLETF untreated control rats.