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Table 1 NASH activity scoring in control and ethanol-treated OLETF and OLET rats.

From: Binge Alcohol Consumption Aggravates Oxidative Stress and Promotes Pathogenesis of NASH from Obesity-Induced Simple Steatosis

 

OLETF rats

OLET rats

Parameters

Control, 33 wks

Ethanol, 5 d/wk

Ethanol, 3 d/wk

Ethanol, 2 d/wk

Ethanol, 1 d/wk

Control, 33 wks

Ethanol, 5 d/wk

Ethanol, 1 d/wk

Steatosis

1.1 ± 0.2

2.1 ± 0.3a

1.9 ± 0.3a

2.0 ± 0.4a

1.9 ± 0.3

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

Lobular inflammation

0.0 ± 0.0

1.4 ± 0.2a

1.3 ± 0.2a

1.1 ± 0.2a

0.8 ± 0.1a

0.0 ± 0.0

0.5 ± 0.1

0.0 ± 0.0

Hepatocyte ballooning

0.2 ± 0.0

2.6 ± 0.4a

2.7 ± 0.4a

2.5 ± 0.3a

2.4 ± 0.3a

0.0 ± 0.0

0.0 ± 0.0

0.0 ± 0.0

NAS (0–9)

1.3 ± 0.2

6.1 ± 0.9a

5.9 ± 0.9a

5.6 ± 0.9a

5.1 ± 0.7a

0.0 ± 0.0

0.5 ± 0.1

0.0 ± 0.0

  1. Data are means ± SD of eight rats per group. Scores for steatosis (score 0–3), lobular inflammation (score 0–3) and hepatocyte ballooning (score 0–3) were summed to produce the NAS, thus ranging from 0 to 9.
  2. aP < 0.001 versus OLETF untreated control rats.