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Figure 1 | Molecular Medicine

Figure 1

From: Human Myocardium Releases Heat Shock Protein 27 (HSP27) after Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 through Toll-like Receptor (TLR)-2 and TLR4

Figure 1

Human and mouse hearts release HSP27/HSP25. (A) Coronary sinus blood is collected from patients before aortic clamping (baseline) and after de-clamping (reperfusion). Heat shock protein 27 (HSP27) and heat shock cognate protein 70 (HSC70) are analyzed by ELISA. Higher levels of HSP27 in coronary sinus blood are evident during reperfusion. Data are presented as mean ± SE. n = 15; *P < 0.05 versus baseline. (B) Hearts from mice are subjected to global ischemia and reperfusion (I/R; I 20 min/R 120 min). Coronary effluent is collected before ischemia and at 0–5, 55–60 or 115–120 min of reperfusion, and HSP25 and HSC70 are analyzed. Hearts release higher levels of HSP25 in early reperfusion. Data are mean ± SE. n = 8; *P < 0.05 versus baseline.

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Molecular Medicine

ISSN: 1528-3658