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Figure 2 | Molecular Medicine

Figure 2

From: Human Myocardium Releases Heat Shock Protein 27 (HSP27) after Global Ischemia: The Proinflammatory Effect of Extracellular HSP27 through Toll-like Receptor (TLR)-2 and TLR4

Figure 2

Extracellular HSP25 mediates postischemic inflammatory response and functional injury in mouse hearts. Mouse hearts are subjected to global ischemia and reperfusion (I/R; I 20 min/R 30 or 120 min). Hearts are treated with an antibody against HSP27/HSP25 (HSP25 antibody [Ab], 1.0 µg/mL) or control IgG (1.0 µg/mL) for 10 min before ischemia and for 20 min after initiation of reperfusion. HSP25 antibody reduces myocardial NF-κB activity and IL-6 levels and improves cardiac functional recovery. Data are mean ± SE. n = 8; *P < 0.05 versus perfusion control (ctrl); #P < 0.05 versus I/R and I/R + IgG. OD, optical density.

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Molecular Medicine

ISSN: 1528-3658