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Figure 2 | Molecular Medicine

Figure 2

From: A Journey in Science: Medical Scientist in Translation

Figure 2

HLA-DR expression in the human atherosclerotic plaque. HLA-DR protein (green) is expressed by most cells in the atherosclerotic plaque (right side) but not in the normal artery adjacent to it (left side). This fluorescent micrograph of a section from a human endarterectomy sample led us to propose that atherosclerosis is an inflammatory disease driven by a local immune reaction. Reproduced from (42): Hansson GK; Jonasson L. The discovery of cellular immunity in the atherosclerotic plaque. Arterioscler. Thromb. Vasc. Biol. 2009;29(11):1714–7.

Also, see (1):

Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis.

L Jonasson, J Holm, O Skalli, G Gabbiani, G K Hansson Published in Volume 76, Issue 1

J Clin Invest. 1985; 76(1):125–131 doi:10.1172/JCI111934

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