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Figure 3 | Molecular Medicine

Figure 3

From: Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function

Figure 3

CXCR4/ACKR3 ligands regulate blood pressure during the cardiovascular stress response to hemorrhage. Rats underwent 40% blood volume (BV) hemorrhage followed by 2% BV hemorrhage every 15 min without intervention. CXCR4/ACKR3 ligands (350 nmol/kg) were injected at t = 15 min (arrow). Open circles: vehicle (n = 19). Yellow squares: AMD3100 (n = 6). Red circles: ubiquitin (n = 8). Blue squares: CXCL12 (n = 8). (A) Blood volume (mL/kg) hemorrhaged. (B) MAP (mmHg). (C) Kaplan-Meier survival curve (dashed line: 50% survival; p < 0.0001 among groups). (D–G) Same hemorrhage model as in A-C. Animals were treated with 350 nmol/kg ubiquitin at t = 15 min (n = 7). At t = 85 min, crystalloid resuscitation to a MAP of 70 mmHg was started. (D) Blood volume (mL/kg) hemorrhaged. (E) MAP (mmHg). (F) Resuscitation fluid requirements (mL/kg). (G) Kaplan-Meier survival curve. For comparison, the line without symbols shows the survival curve from animals after vehicle treatment (from C).

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Molecular Medicine

ISSN: 1528-3658