Chemokine (C-X-C Motif) Receptor 4 and Atypical Chemokine Receptor 3 Regulate Vascular α1-Adrenergic Receptor Function

Table 1 Receptor selectivity of CXCR4 and ACKR3 ligands and their effects on α₁-AR-mediated vasoconstriction of isolated mesenteric arteries.

		Receptor selectivity		Effect on vascular α-AR reactivity
Ligand	CXCR4	ACKR3	References	Effect on vascular α-AR reactivity
CXCL11	NB	+	(1,48)	↓
CXCL12	+	+	(1,6,7)	↓
TC14012	−	+	(44)	↓
11G8	NB	+	(49)	↓
CCX771	NB	+	(25)	↓
AMD3100	−	NB	(1,67,68)	∼
Ubiquitin	+	NB	(1,18,42)	↑

NB, not binding; +, agonist; (+), weak allosteric agonist; −, antagonist; ↓, antagonizes phenylephrine-induced vasoconstriction; ↑, enhances phenylephrine-induced vasoconstriction; ∼, no effect on phenylephrine-induced vasoconstriction.

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