Skip to main content
Figure 1 | Molecular Medicine

Figure 1

From: Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury

Figure 1

Adoptive transfer of Ad-HO-1 BMMs prevents IR-induced hepatocellular damage in Nrf2-deficient mice. BMMs transfected (5 × 106) with Ad-HO-1 or Ad-β-gal (2.5 × 109 pfu) or untreated BMMs were infused into Nrf2 KO mice (via portal vein) at 24 h before 90 min of ischemia. Animals were killed at 6 h of reperfusion. (A) Representative histological staining (H&E) of ischemic liver tissue. Scale bars indicate 50 µm. (B) Liver damage, evaluated by Suzuki histological score. *p < 0.05. (C) Hepatocellular function, assessed by sALT levels (IU/L). *p < 0.005; **p < 0.0005. Mean ± SD are shown (n = 4–6/group).

Back to article page

Molecular Medicine

ISSN: 1528-3658