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Figure 7 | Molecular Medicine

Figure 7

From: Adoptive Transfer of Heme Oxygenase-1 (HO-1)-Modified Macrophages Rescues the Nuclear Factor Erythroid 2-Related Factor (Nrf2) Antiinflammatory Phenotype in Liver Ischemia/Reperfusion Injury

Figure 7

Scheme of signaling pathways by which the Nrf2-HO-1 axis may regulate inflammatory responses in liver IRI. HO-1 rescues Nrf2-dependent antiinflammatory functions by activating Notch1/Hes1/Stat3 and reprogramming macrophages toward the M2 phenotype. This step, in turn, upregulates antiinflammatory IL-10/TGF-β, leading to inhibition of NF-κB activation and inflammatory responses in IR-stressed livers. Furthermore, HO-1-mediated Stat3 activation promotes PI3K/Akt signaling to increase cell survival and enhance antiapoptotic activity, which may also exert hepatoprotection in IR-stressed livers.

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Molecular Medicine

ISSN: 1528-3658