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Figure 1 | Molecular Medicine

Figure 1

From: Reg3α Overexpression Protects Pancreatic β Cells from Cytokine-Induced Damage and Improves Islet Transplant Outcome

Figure 1

Reg3α overexpression in islet grafts improved glycemic control in streptozotocin-induced diabetic mice. (A) Random blood glucose levels in diabetic mice receiving Reg3α-transduced islets (Reg3α, n = 11) or EGFP vector-transduced islets (EGFP n = 9), and mock-treated mice (Mock, n = 7) groups were measured after transplantation. (B) IPGTT was performed at 15 d after transplantation. Blood glucose levels were measured after glucose loading at indicated time. (C) Area under curve (AUC) of IPGTT was calculated to compare the differences among each group. (D) During IPGTT, serum insulin levels were determined before and 30 min after glucose infusion. Values represent the means ± SEM, *P < 0.05 denoted significance between Reg3α group and EGFP or Mock group.

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Molecular Medicine

ISSN: 1528-3658