Figure 1

GNMT deficiency impaired development of EAE. 8- to 12-wk-old female wild-type, Gnmt^−/− mice were induced with EAE by immunization with 200 µg of MOG_35–55 emulsified in CFA and co-injection with pertussis toxin. (A) Mean clinical scores of diseased mice. (B) Incidence of EAE. Pooled data of two independent experiments including 7–12 mice per group are presented. Data are presented as mean clinical scores ± SEM. Statistics were calculated by the Student t test (A) and the χ² test (B), respectively. *p < 0.05; **p < 0.01.