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Figure 8 | Molecular Medicine

Figure 8

From: Investigation on the Origin of Sperm DNA Fragmentation: Role of Apoptosis, Immaturity and Oxidative Stress

Figure 8

A scheme to summarize the results of the study. Lane 1: Live cells arriving in the ejaculate without DNA damage. Lane 2: Immature live cells arriving in the ejaculate without DNA damage. Lanes 3 and 4: Apoptotic cells evolving as DNA fragmented and dead (or directly dead). In Lane 4, apoptosis is induced by maturation impairment. These cells go through the genital tracts without being further DNA damaged by oxidative stress. Lane 5: Live cells undergoing oxidative damage just before ejaculation and thus not experiencing apoptosis. Lane 6: Live cells undergoing oxidative damage triggering apoptosis but not DNA fragmentation. Lane 7: Live cells undergoing oxidative damage triggering apoptosis and DNA fragmentation. Lane 8: Live cells undergoing oxidative damage triggering apoptosis, DNA fragmentation and death.

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Molecular Medicine

ISSN: 1528-3658