Figure 3From: Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)Blockade of MRPs induces vacuole formation in acinar cells of secretin-treated rats. Hematoxylin and eosin sections of pancreas from control (A), probenecid (B), probenecid + ANF (C), probenecid + secretin (D) and probenecid + secretin + ANF (E) are shown. Small and large vacuoles were observed in groups D and E (arrowheads). Each is a representative photograph (400× magnification).Back to article page