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Figure 5 | Molecular Medicine

Figure 5

From: Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

Figure 5

Secretin aggravates cerulein-induced acute pancreatitis and ANF reduces secretin response, but MRP inhibition further aggravates cerulein-induced acute pancreatitis in the presence of secretin and blunts ANF response. (A–D) Hematoxylin and eosin section of pancreas from rats with acute pancreatitis induced by cerulein and infused with secretin alone or with ANF. Control (A), ANF (B), secretin (C), and secretin + ANF (D) are shown. Higher vacuolization and areas of necrosis were observed in (C). Each is a representative photograph (400× magnification). (E–H) Hematoxylin and eosin section of pancreas from rats with acute pancreatitis induced by cerulein and infused with secretin alone or with ANF in the presence of probenecid pretreatment. Probenecid (E), probenecid + ANF (F), probenecid + secretin (G), and probenecid + secretin + ANF (H) are shown. Higher areas of necrosis and larger vacuoles were observed in (G) and (H). Each is a representative photograph (400× magnification).

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Molecular Medicine

ISSN: 1528-3658