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Figure 6 | Molecular Medicine

Figure 6

From: Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

Figure 6

Schematic representation of the proposed action of ANF, secretin and MRP4 (MRP-4) in pancreatic acinar cells. Stimulation of secretin receptors leads to adenylyl cyclase activation, and the rise of intracellular cAMP is regulated by the action of PDEs and the exclusion of the second messenger through MRP4. ANF by activating NRP-C receptors potentiates cAMP efflux. Marked cAMP elevation as induced by secretin and MRP4 blockade by probenecid or MK571 leads through downstream effectors to trypsinogen activation and eventual damage of acinar cells. AC, adenylyl cyclase; e-cAMP, extracellular cAMP; i-cAMP, intracellular cAMP; SECRETIN-R, secretin receptor.

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Molecular Medicine

ISSN: 1528-3658