Table 1 Histological examination of the exocrine pancreas with or without probenecid (P) pretreatment and infused with secretin (S) alone or with ANF.
Apical | Vascular | Necrotic | Pyknotic | |||
|---|---|---|---|---|---|---|
granules | Edema | congestion | Vacuoles | areas/field | nuclei/field | |
Control | 2 | 0 | 0 | 0 | 0 | 0–1 |
ANF | 2 | 0 | 0 | 0 | 0 | 1 |
Secretin | 4 | 0 | 0 | 0 | 0 | 0–1 |
S + ANF | 4 | 0 | 0–1 | 0 | 0 | 1 |
Probenecid | 2 | 0 | 0 | 0 | 0 | 0–1 |
P + ANF | 2 | 0 | 0–1 | 0–1 | 0–1 | 1 |
P + S | 3 | 0–1 | 0 | 1 | 0–1 | 0–1 |
P + S + ANF | 2–3 | 0–1 | 0 | 1 | 0–1 | 1–2 |