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Table 2 Histological examination of the exocrine pancreas in cerulein-treated rats (C) pretreated with secretin (S) alone or with ANF in the absence or presence of probenecid (P).

From: Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor’s Beneficial Effect in Rats: Role of MRP4 (ABCC4)

 

Apical

 

Vascular

 

Necrotic

Pyknotic

 

granules

Edema

congestion

Vacuoles

areas/field

nuclei/field

C

1–2

1

2

1–2

2

1–2

C + ANF

1–2

1–2

2–3

1–2

2

2–3

C + S

1–2

3

4

2

2–3

1–2

C + S + ANF

1–2

2

2–3

2

3

4

P + C

1–2

1

2

1–2

2

1–2

P + C + ANF

1

2

3

3

3–4

4

P + C + S

1

4

4

4

3–4

2

P + C + S + ANF

1

4

4

4

4

4

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Molecular Medicine

ISSN: 1528-3658