Figure 2
From: Discovery of a Master Regulator of Injury and Healing: Tipping the Outcome from Damage toward Repair
EPO is a master regulator of injury and repair. EPO produced locally in response to injury or metabolic stress prevents injury and attenuates inflammation, reducing the cascade of proinflammatory cytokines. Simultaneously, EPO activates tissue repair. This process includes the recruitment of stem cells into the region of injury, for example, progenitor vascular endothelial cells that participate in angiogenesis, leading to tissue regeneration.