Figure 4
From: Discovery of a Master Regulator of Injury and Healing: Tipping the Outcome from Damage toward Repair
EPO binding the homodimeric receptor mediating red cell production via binding sites located on each receptor monomer (sites 1 and 2, as indicated in the dashed boxes). The portions of the EPO molecule interacting with the receptor consist of portions of helices A, C and D. In contrast, helix B faces away from the receptor. The exterior portion of helix B (dashed ellipse) is highly conserved from an evolutionary perspective and binds to the IRR, a heteromeric receptor consisting of EPOR and β common receptor subunits. Image reproduced from (18) (copyright © 2008 by The National Academy of Sciences of the USA).