Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

Table 1 Inhibition of HMGB1 in experimental models of pain.

Pain model	Nociceptive assessment	HMGB1 inhibition	Route of drug administration	Species	Reference
Nerve injury pain
SNL	Mechanical (VF); thermal (hotplate)	HMGB1 Ab	Peri-sciatic	Rat	56
Nucleus pulposus	Mechanical (VF)	HMGB1 Ab	Intraperitoneal	Rat	76
TNI	Mechanical (VF)	Glycyrrhizin	Intraperitoneal	Rat	37
Diabetes	Mechanical (VF)	HMGB1 Ab	Intrathecal	Mouse	80
PSNL	Mechanical (VF)	HMGB1 Ab	Intravenous	Rat	75
Inflammatory pain
LPS paw	Mechanical (VF); thermal (thermal analgesia meter)	HMGB1 Ab	Intraplantar	Rat	59
LPS paw	Mechanical (VF); thermal (thermal analgesia meter)	HMGB1 Ab	Intraplantar	Rat	59
Arthritis	Mechanical (VF)	HMGB1 Ab; Abox	Intrathecal	Mouse	65
Other pain
Bone cancer	Mechanical (VF)	HMGB1 Ab	Intrathecal	Rat	79
Cyclophosphamide-induced bladder pain	Mechanical (VF)	Thrombomodulin; HMGB1 Ab	Intraperitoneal	Mouse	61

SNL, spinal nerve ligation; VF, von Frey filaments; Ab, antibody; TNI, tibial nerve injury;PSNL, partial sciatic nerve ligation; CCI, chronic constriction induced.

ISSN: 1528-3658