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Figure 3 | Molecular Medicine

Figure 3

From: Galectin-3 Ablation Enhances Liver Steatosis, but Attenuates Inflammation and IL-33-Dependent Fibrosis in Obesogenic Mouse Model of Nonalcoholic Steatohepatitis

Figure 3

Galectin-3 deficiency attenuated HFD-induced recruitment of proinflammatory monocytes/macrophages in liver. Flow cytometric analysis of liver MNCs. (A) CD11b+Ly6ChiLy6G− cells with representative FACS plots. (B) Proinflammatory macrophages with representative FACS plots. Hepatic mRNA expression for F4/80, CCL2, TNF-α IL-6, NLRP3, caspase-1 and IL-1β. (D) M1 (F4/80+CD11c+CD206) and M2 (F4/80+CD11c−CD206+) macrophages. (E) Hepatic mRNA expression for Nox2, p22phox, p47phox and p65phox. The results are shown as the means ± SEM (n = 5–6 mice/group/experiment). *P < 0.05. The results are representative of two experiments.

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Molecular Medicine

ISSN: 1528-3658