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Figure 4 | Molecular Medicine

Figure 4

From: C1q-Mediated Repression of Human Monocytes Is Regulated by Leukocyte-Associated Ig-Like Receptor 1 (LAIR-1)

Figure 4

LAIR-1 engagement induces an interaction between LAIR-1 and SHP-1, but CpG stimulation induces an interaction of Hck with LAIR-1. (A) Human monocytes were stimulated with CpG, C1q, CpG plus C1q or CpG plus anti-LAIR-1 antibody for 30 min. Cell lysates were immunoprecipitated with anti-LAIR-1 antibody, and LAIR-1 binding proteins were analyzed by Western blot. Data are representative of three independent experiments. (B) Cells were stimulated for the indicated time, and the same experiment as in (A) was performed. Numbers in blots represent density, and relative bindings were calculated by the ratio for the immune-precipitated LAIR-1. Experiments were repeated three times, and representative data are shown.

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Molecular Medicine

ISSN: 1528-3658