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Figure 2 | Molecular Medicine

Figure 2

From: H5N1 Virus Hemagglutinin Inhibition of cAMP-Dependent CFTR via TLR4-Mediated Janus Tyrosine Kinase 3 Activation Exacerbates Lung Inflammation

Figure 2

JAK3 activation by H5N1 HA inhibits AC activity and reduces the cAMP level. Cultured bronchial epithelial cells (16HBE) were pretreated with JAK3 inhibitor VI (JAK3inh, 760 nmol/L) or saline for 30 min prior to HA (40 µg/mL) treatment. Then, 10 min or 20 min after the HA challenge, (A) the intracellular cAMP levels and (B) the adenylyl cyclase activity in these cells were evaluated via ELISA. *p < 0.05 versus control cells treated with saline or cells treated with HA alone.

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Molecular Medicine

ISSN: 1528-3658