Figure 5

Effect of valsartan administration on Th1, Th2 and Th17 cells and Tregs in the spleen of Ang II-treated ApoE^−/− mice. (A) CD4⁺ T-cell subsets were gated (a). Representative pictures of Th1 cells (b), Th2 cells (c), Th17 cells (d) and Tregs (e) are shown. The numbers in the upper right quadrants indicate positive percentages of these cells. (B) Results of statistical analysis of Th1 cells (**p < 0.01 versus group II). (C) Results of statistical analysis of Th2 cells (*p < 0.05 versus group II; **p < 0.01 versus group II). (D) Results of statistical analysis of Th17 cells (**p < 0.01 versus group II). (E) Results of statistical analysis of Tregs (*p < 0.05 versus group II). The values are presented as the mean ± SD; n = 5–7.