Figure 6

ABL does not act directly on proinflammatory signaling. (A) p-Akt, p-ERK, p-JNK, p-p38, p-NF-κB and Ac-NF-κB in brain tissues of pAd-miR-155-infected mice and miR-155^−/− mice treated with or without ABL (20 mg/kg) were detected by Western blotting, and band intensities that were normalized to β-actin are represented by bar graphs as the means ± SD (n = 6 per group); *P < 0.05 versus pAd + MCAO; ^#P < 0.05 versus WT + MCAO. (B) BV2 cells were treated with or without ABL (100 µmol/L) for 24 h prior to OGD. p-Akt, p-ERK, p-JNK, p-p38 and Ac-NF-κB were detected by Western blotting, and band intensities that were normalized to β-actin are represented by bar graphs as the means ± SD from three independent experiments; *P < 0.05 versus con group.