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Figure 4 | Molecular Medicine

Figure 4

From: Preserved Expression of mRNA Coding von Willebrand Factor-Cleaving Protease ADAMTS13 by Selenite and Activated Protein C

Figure 4

Decrease of ADAMTS13 expression is abrogated by selenite and APC. (A) ADAMTS13 transcripts decreased in HSCs after stimulation with serum from septic patients (SepSe). Costimulation with APC (SepSe + APC) and selenite (SepSe + selenite) for 6 h or 24 h nullified ADAMTS13 transcript reduction as normalized to ADAM9 and HPRT. (B) The decrease of ADAMTS13 transcripts in HMEC is nullified after costimulation with APC (SepSe + APC) and selenite (SepSe + selenite) for 6 h or 24 h. (C) APC-mediated rescue of ADAMTS13 is triggered via the endothelial protein C receptor (EPCR) in endothelial cells. (D) Coadministration of APC and selenite increased ADAMTS13 mRNA transcription rate slightly. Bars represent mean values of log2-ratios ± SEM for at least four independent experiments.

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Molecular Medicine

ISSN: 1528-3658