Figure 5
From: Interleukin-9 Is Associated with Elevated Anti-Double-Stranded DNA Antibodies in Lupus-Prone Mice
Neutralization of IL-9 and IL-17 can relieve lupus nephritis. (A) MRL/lpr mice were treated with vehicle, IL-9-neutralizing antibody or IL-9- and IL-17-neutralizing antibody every 4 wks for 12 wks. Serum titers of dsDNA antibody were analyzed by ELISA (n = 6 animals/group). (B) The renal score of MRL/lpr mice that were treated with vehicle or IL-9- and IL-17-neutralizing antibody were calculated (n = 6 animals/group). (C) Urinary protein levels were measured by ELISA (n = 6 animals/group). (D) Hematoxylin and eosin staining of the kidneys (100× magnification).