Figure 6
The effect of ROSI on insulin signaling cascades in liver tissue of rats after MI. (A) Tyrosine phosphorylation of IRS1. (B) Serine phosphorylation of Akt (ser 473). Rats were administered with ROSI (4 mg/kg) and all of them received insulin injection before being killed. Upper panel, representative immunoblots are shown. Lower panel, quantification of phosphorylation blots relative to their corresponding loading. Tyrosine phosphorylation of IRS1 relative to IRS1, serine phosphorylation of Akt (ser 473) relative to Akt. Values presented are means ± SEM of 4 to 5 samples in each group. *P < 0.05 versus control group. #P < 0.05 versus MI group.