Figure 6
From: Role of Interleukin-1 in Radiation-Induced Cardiomyopathy
IL-1 blockade had no effects on myocardial and pericardial fibrosis. Masson’s trichrome was used to assess the total amount of interstitial collagen and the pericardial fibrosis at 4 months (20 Gy) after XRT. (A) Quantification of the myocardial interstitial fibrosis in wt mice, anakinra-treated mice and IL-1RI KO mice. (B) Representative images of the pericardial thickness in sham and wt or IL-1RI KO mice. (C) Quantification of the pericardial thickness in the groups of sham and 20 Gy irradiated mice. Anakinra-treated groups were compared with the sham-wt group.