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Table 1 Hemodynamic parameters.

From: Role of Interleukin-1 in Radiation-Induced Cardiomyopathy

Groupa

LVPSP (mmHg)

LVEDP (mmHg)

+dP/dt (mmHg/s)

−dP/dt (mmHg/s)

Sham-wt

66.3 ± 3.7

3.6 ± 0.5

+3,708 ± 205

−3,375 ± 279

Sham-IL-1R1 KO

57.3 ± 2.3

2.4 ± 0.4

+2,975 ± 210

−2,900 ± 247

20Gy-wt

67.5 ± 2.2

7.8 ± 1.0b

+3,450 ± 319

−3,225 ± 248

20Gy-IL-1R1 KO

63.6 ± 2.6

8.1 ± 4.2c

+3,528 ± 985

−2,500 ± 658

20Gy-wt+anakinra

72.2 ± 3.1

9.1 ± 2.7b

+3,650 ± 650

−2,750 ± 450

  1. aSee Experimental Groups in Materials and Methods for information on the groups.
  2. bP < 0.05 versus sham-wt.
  3. cP = 0.05 versus sham-IL-1RI KO.
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Molecular Medicine

ISSN: 1528-3658