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Figure 3 | Molecular Medicine

Figure 3

From: Glucagon-Like Peptide 1 Protects against Hyperglycemic-Induced Endothelial-to-Mesenchymal Transition and Improves Myocardial Dysfunction by Suppressing Poly(ADP-Ribose) Polymerase 1 Activity

Figure 3

GLP-1 inhibited HG-induced EndMT in vitro and in vivo. (A) Confocal microscopy of vWF (green), α-SMA (red), DAPI (blue) in mouse diabetic hearts. Colocalization of vWF and α-SMA expression in heart tissues in yellow. (B) Quantification of α-SMA staining cells in diabetic hearts. (C) vWF and α-SMA staining quantification to total α-SMA staining in diabetic hearts. (D) Morphological changes in HAECs were observed by microscopy (10×). (E) Immunofluorescence staining with antibodies to VE-cadherin (red) and α-SMA (green). Nuclei were counterstained with DAPI (blue nuclei). Data are mean ± SD; n = 6–7 per group. #p < 0.05 versus control; *p < 0.05 versus DM.

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Molecular Medicine

ISSN: 1528-3658