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Figure 4 | Molecular Medicine

Figure 4

From: Glucagon-Like Peptide 1 Protects against Hyperglycemic-Induced Endothelial-to-Mesenchymal Transition and Improves Myocardial Dysfunction by Suppressing Poly(ADP-Ribose) Polymerase 1 Activity

Figure 4

GLP-1 inhibited HG-induced PARP-1 expression and activity by reducing ROS production in HAECs. Immunofluorescent staining of intracellular ROS production (A) and quantification with and without NAC and GLP-1 (B) are shown. (C, D) Western blot analysis of PARP-1 and PAR protein expression. Results are from three repeated experiments. Data are means ± SD. #p < 0.05 versus NG, *p < 0.05 versus HG.

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Molecular Medicine

ISSN: 1528-3658