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Figure 7 | Molecular Medicine

Figure 7

From: Glucagon-Like Peptide 1 Protects against Hyperglycemic-Induced Endothelial-to-Mesenchymal Transition and Improves Myocardial Dysfunction by Suppressing Poly(ADP-Ribose) Polymerase 1 Activity

Figure 7

GLP-1 reduced HG-induced collagen I, collagen III, MMP-2 and MMP-9 expression in HAECs with siPARP-1 or GLP-1. (A, B) Western blot analysis of collagen I and III expression. Data are mean ± SD. #p < 0.05 versus NG, *p < 0.05 versus HG. (C, D) Gelatin zymography analysis of MMP-2 and MMP-9 activity. Results are from three repeated experiments. Data are mean ± SD. #p < 0.05 versus NG, *p < 0.05 versus HG.

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Molecular Medicine

ISSN: 1528-3658