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Figure 8 | Molecular Medicine

Figure 8

From: Glucagon-Like Peptide 1 Protects against Hyperglycemic-Induced Endothelial-to-Mesenchymal Transition and Improves Myocardial Dysfunction by Suppressing Poly(ADP-Ribose) Polymerase 1 Activity

Figure 8

GLP-1 prevented HG-induced endothelial cell migration. (A) Migration immediately after the scratching and 8 and 24 h later. Magnification 10×. Data are from at least three repeated experiments. (B) Quantification of the migration ability at 8 and 24 h after scratching. Data are mean ± SD. #p < 0.05 versus NG, *p < 0.05 versus HG. (C) Transitioned endothelial cells (VE-cadherin to α-SMA cell ratio) contribute to faster migration capacity in endothelial cells exposed to HG with siPARP-1 or GLP-1. Double immunofluorescence staining with antibody to VE-cadherin (red) and α-SMA (green). Nuclei were stained with DAPI (blue). Results are from 3 repeated experiments. Scale bar (C), 100 µm.

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Molecular Medicine

ISSN: 1528-3658