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Figure 2 | Molecular Medicine

Figure 2

From: Mouse Model for Protein Tyrosine Phosphatase D (PTPRD) Associations with Restless Leg Syndrome or Willis-Ekbom Disease and Addiction: Reduced Expression Alters Locomotion, Sleep Behaviors and Cocaine-Conditioned Place Preference

Figure 2

Initial characterization of PTPRD knockout mice. (A) Reduced PTPRD expression significantly decreased weight (ANCOVA effect of genotype, p = 0.002), with especial influence on homozygous knockouts. (B) Reduced PTPRD expression reduced strength/motor persistence in screen hang-time testing (effect of genotype, p = 0.031). Scheffé post hoc testing did not reveal any differences between heterozygous and wild-type mice (p = 0.831). (C) Reduced PTPRD expression did not significantly influence performance in rotarod testing (ANCOVA, p = 0.600). Data presented are mean ± SEM, n = 8–12/genotype. *p < 0.05, ***p < 0.001.

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Molecular Medicine

ISSN: 1528-3658