Skip to main content
Figure 6 | Molecular Medicine

Figure 6

From: Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by dl-α-Lipoic Acid

Figure 6

Altered mitochondrial function in liver mitochondria of STZ-diabetic rats. Comparison of mitochondrial oxygen consumption rate (OCR) of liver mitochondria isolated from control (CTL) and streptozotocin-diabetic (STZ) rats is shown in (A,B) coupling and (C,D) electron flow experiments. Note the suppression of the FCCP-induced oxygen consumption responses (respiratory reserve capacity, state 3u) by diabetes in the coupling experiment, and the suppression of all bioenergetic parameters in the electron flow experiment. A–B show measurement of bioenergetics tracings and C–D show mean ± SEM values collected from five individual measurements conducted on different experimental days; **p < 0.01 shows significant differences between control and diabetic mitochondria for the indicated functional parameter.

Back to article page

Molecular Medicine

ISSN: 1528-3658