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Figure 9 | Molecular Medicine

Figure 9

From: Regulation of Vascular Tone, Angiogenesis and Cellular Bioenergetics by the 3-Mercaptopyruvate Sulfurtransferase/H2S Pathway: Functional Impairment by Hyperglycemia and Restoration by dl-α-Lipoic Acid

Figure 9

Impairment of the 3-MP/3-MST system in hyperglycemia/diabetes; restoration by lipoic acid (DHLA) proposed mechanisms. (A) Normal conditions, physiological levels of endogenous DHLA permit the normal function of 3-MST, yielding H2S production from 3-MST. (B) Hyperglycemic conditions, overproduction of reactive oxygen and nitrogen species (ROS, RNS) impairs the 3-MP/3-MST system, by consuming DHLA, and/or by directly and reversibly inactivating 3-MST. (C) DHLA supplementation during hyperglycemic conditions improves the function of the 3-MP/3-MST system.

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Molecular Medicine

ISSN: 1528-3658