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Figure 3 | Molecular Medicine

Figure 3

From: Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

Figure 3

Effect of high glucose level at 25 mmol/L on Klf4 and myocardin mRNA and protein expression in cultured vascular smooth muscle cells. Quantitative analysis of Klf4 (A) and myocardin (B) mRNA levels. The values from VSMCs under high glucose treatment have been normalized to matched GAPDH measurement and then expressed as a ratio of normalized values to mRNA in control group. *P < 0.05 versus control. #P < 0.01 versus control. +P < 0.01 versus control. (n = 4 per group. (C) Representative Western blots for Klf4 and myocardin in VSMCs after high glucose at 25 mmol/L for various periods of time. (D) Quantitative analysis of Kfl4 and myocardin protein levels. The values from VSMCs after high glucose treatment have been normalized to matched α-tubulin measurement and then expressed as a ratio of normalized values to protein in control group. *P < 0.05 versus control. #P < 0.01 versus control. +P < 0.01 versus control. n = 4 per group.

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Molecular Medicine

ISSN: 1528-3658