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Figure 4 | Molecular Medicine

Figure 4

From: Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

Figure 4

Angiotensin II mediates the increase of Klf4 and myocardin protein expression by high glucose in vascular smooth muscle cells. (A and C) Representative Western blots for Klf4 and myocardin protein levels in VSMCs subjected to high glucose stimulation for 6 h in the absence or presence of valsartan, angiotensin II receptor (ATR1) siRNA or angiotensin II (Ang II). (B and D) Quantitative analysis of Klf4 and myocardin protein levels. The values from stimulated VSMCs have been normalized to values in control cells. #P < 0.01 versus control. +P < 0.01 versus 6 h. §P < 0.01 versus 6 h. n = 4 per group.

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Molecular Medicine

ISSN: 1528-3658