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Figure 6 | Molecular Medicine

Figure 6

From: Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

Figure 6

Effect of high glucose and angiotensin II on HCASMCs proliferation and migration. (A) DNA synthesis by Alamar blue assay. *P < 0.01 versus control. +P < 0.01 versus hyperglycemia (25 mmol/L glucose). n = 4 per group. (B) HCASMCs migrated through filter were stained. HCASMCs treated with hyperglycemia and Ang II for 6 h in the presence or absence of WT miR-145, antagomir-145, Klf4 siRNA, or valsartan. (C) Migration of HCASMCs was quantified by staining and counting the number of cells that migrated to the bottom of the filter in five fields under a 400× high-power field (HPF). (n = 4 per group). #P < 0.001 versus control (lane 1). *P < 0.001 versus hyperglycemia (lane 2).

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Molecular Medicine

ISSN: 1528-3658