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Figure 7 | Molecular Medicine

Figure 7

From: Angiotensin II Downregulates MicroRNA-145 to Regulate Kruppel-like Factor 4 and Myocardin Expression in Human Coronary Arterial Smooth Muscle Cells under High Glucose Conditions

Figure 7

Proposed signal pathway of high glucose on the regulation of miR-145 and Klf4 and myocardin for proliferation and migration in vascular smooth muscle cells. High glucose increases Ang II expression and Ang II through angiotensin receptor downregulates miR-145. miR-145 downregulates Klf4 and Klf4 downregulates myocardin expression, finally causing smooth muscle cell proliferation and migration to promote atherogenesis.

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Molecular Medicine

ISSN: 1528-3658