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Figure 4 | Molecular Medicine

Figure 4

From: Virus-Mediated Knockdown of Nav1.3 in Dorsal Root Ganglia of STZ-Induced Diabetic Rats Alleviates Tactile Allodynia

Figure 4

Cutaneous receptive fields of WDR units. (A) A representative map shows sampled WDR neuron receptive fields from each group. (B) STZ-induced diabetic animals exhibited enlarged receptive fields, as observed previously (41). Viral-mediated knockdown of Nav1.3 (with shRNA-Nav1.3) reduced the size of the enlarged receptive field compared with receptive fields in animals that received control, scrambled vectors (shRNA-Sc) (*p < 0.05; n = 16). Graph is mean ± SEM.

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Molecular Medicine

ISSN: 1528-3658