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Figure 5 | Molecular Medicine

Figure 5

From: An EG-VEGF-Dependent Decrease in Homeobox Gene NKX3.1 Contributes to Cytotrophoblast Dysfunction: A Possible Mechanism in Human Fetal Growth Restriction

Figure 5

Effect of NKX3.1 downregulation on cell differentiation in BeWo cells. (A) Quantification of the downregulation of NKX3.1 mRNA expression following treatment with NKX3.1 siRNA. (B) Shows a representative Western blot and quantification of the downregulation of NKX3.1 protein following the treatment with NKX3.1 siRNA. Cells were analyzed for the downregulation of NKX3.1 mRNA and protein expressions 72 h after transfection. Nonspecific siRNA served as control siRNA. (C) Expression of NKX3.1 mRNA in FSK ± EG-VEGF-treated BeWo cells. (D) Effect of NKX3.1 downregulation on CGB mRNA expression and β-hCG protein secretion in BeWo cells. Results are reported as the mean ± SE mol/L from n = 3 independent experiments. Data were analyzed using the Mann-Whitney U test (significant differences, *p < 0.05).

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Molecular Medicine

ISSN: 1528-3658