Figure 2
From: Humanin Derivatives Inhibit Necrotic Cell Death in Neurons
The protective effect of AGA(C8R)-HNG17 in mice against TBI. (A) Experimental design for the data obtained in vivo. (B) MRI scans of representative mice brains: median mouse from each group with the group average values given below each image ± standard deviation. (C) Neuronal severity score for groups of mice treated with vehicle (n = 8), 0.04 mg/kg (n = 8) or 0.4 mg/kg (n = 10) of AGA(C8R)-HNG17, tested 1 and 24 h after TBI. *P ≤ 0.002 (t test) compared with vehicle measurement on the same time point. (D) Graph showing the average values of brain edema for the groups of mice treated with different concentrations of AGA(C8R)-HNG17 (n = 8 for 0.04 and n = 10 for 0.4 mg/kg) or vehicle (n = 8) as a percent of the brain volume. MRI scans were performed 1 h and 1, 2 and 7 d after TBI. *P ≤ 0.05 (t test) compared with the respected time-point vehicle group value.