Figure 2
From: Targeting Extracellular Cyclophilins Ameliorates Disease Progression in Experimental Biliary Atresia
MM284 prevented weight loss in newborn mice with biliary atresia induced by rhesus rotavirus. Newborn BALB/c mice were either pretreated with MM284 on the first day of life and injected with Rhesus Rotavirus (RRV) 24 h posttreatment (A) or infected with RRV and then treated with MM284 on d 1 postinfection (B). Subsequent MM284 injections were performed on d 4, 6, 8, 10 and 12 (A), or on d 2, 3, 4, 6, 8, 10 and 12 (B). Weight was measured daily from d 7 to d 14 when the animals were killed. Results are shown as a mean ± SD for each group. Asterisks represent p values <0.05. (C) Bilirubinuria was measured on d 14 in a group of untreated mice (n = 23) and compared with a combined group of mice pretreated or posttreated with MM284 (n = 20). Results were compared using chi-square test and the p value is shown above the bars.