Figure 3
From: Targeting Extracellular Cyclophilins Ameliorates Disease Progression in Experimental Biliary Atresia
MM284 reduced inflammation in the liver of mice with RRV-induced BA. (A) Myeloperoxidase staining of liver tissue. Representative images are shown for three groups of animals. (B, C) Quantitative RT-PCR analysis of TIMP-4 mRNA in the liver extracts of RRV-infected mice pretreated (B) or posttreated (C) with MM284. Results are shown as mean ± SD of three independent experiments. Asterisks represent p values <0.05 between RRV and RRV + MM284 groups. The pound sign represents p values <0.05 between RRV + MM284 and control groups. (D,E) Quantitative RT-PCR analysis of MMP-7 mRNA in the liver extracts of RRV-infected mice pretreated (D) or posttreated (C) with MM284. Results are shown as mean ± SD of three independent experiments. Asterisks represent p values <0.05 between the RRV and RRV + MM284 groups. The pound sign represents p values <0.05 between the RRV + MM284 and control groups. (F,G) Quantitative RT-PCR results of IL-6 mRNA in the liver extracts of RRV-infected mice pretreated (F) or posttreated with MM284 (G). Asterisks represent p value <0.01 between RRV and RRV + MM284 groups, and the pound sign represents p values <0.05 between RRV + MM284 and control groups.