Figure 5From: Targeting Extracellular Cyclophilins Ameliorates Disease Progression in Experimental Biliary AtresiaSchematic representation of the effects of extracellular CypA and MM284 in experimental BA. Extracellular CypA produced by resident liver cells attracts inflammatory cells and stimulates them to produce IL-6. It also activates the SMAD pathway resulting in production of TIMP-4, MMP-7 and other mediators. Question marks denote effects with unknown mechanism.Back to article page