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Figure 3 | Molecular Medicine

Figure 3

From: Simvastatin and a Plant Galactolipid Protect Animals from Septic Shock by Regulating Oxylipin Mediator Dynamics through the MAPK-cPLA2 Signaling Pathway

Figure 3

Comparative metabolomic profiling of systemic and organ-specific oxylipin mediators. (A) Total serum and (B) liver levels of oxylipin metabolites from the LOX, COX, CYP450 and sEH pathways. Concentrations are expressed in pg/mg and pg/mL in liver samples and serum samples, respectively. PLS-DA score plot and corresponding loadings plot derived from the quantified oxylipin levels in the (C) sera and (D) liver of the vehicle control, LPS only, and the different treatment groups. Corresponding heat maps are shown with oxylipin metabolites grouped according to precursor compounds (LA, AA, DHA and EPA) and the corresponding enzymes. DHA and EPA metabolites were not detected from the serum. (N = 4 per treatment group).

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Molecular Medicine

ISSN: 1528-3658