Figure 4
Quantitative comparison of individual oxylipin metabolite levels with significant contribution to the PLS-DA metabolite clustering in the sera and liver of septic mice. Concentrations are expressed in pg/mg and pg/mL for the liver sample and serum sample, respectively. Major contributors to (A) serum and (B) liver PLS-DA clustering were identified based on the loadings plot and quantified oxylipin levels. (C) Serum levels of proresolution and antiinflammatory oxylipins, LXA4, 5(6)-EET, 11(12)-EET and 15-deoxy-PGJ2, as well as hepatic levels of precursor DHA and EPA, corresponding proresolution metabolites resolvin D1, 17-HDoHE, 10,17-DiHDoHE, and 5-HEPE, increased by either dLGG or simvastatin treatment are shown (N = 4, P < 0.05, ANOVA, post hoc LSD; values with different letters are significantly different).