Figure 4From: High Mobility Group Box Protein 1 (HMGB1): The Prototypical Endogenous Danger MoleculeP5779 as an HMGB1 antagonist targeting MD-2. Disulfide HMGB1 binds to MD-2, and this interaction is critically important for HMGB1-TLR4-mediated immune responses. P5779 also binds to MD-2 and thus prevents the HMGB1-MD-2 interaction and subsequent TLR4-dependent signaling and immune response, thereby inhibiting HMGB1-induced cytokine release and toxicity.Back to article page