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Table 2 Porphyrin precursor and porphryin levels in AIP and control livers.

From: Liver Transplantation for Acute Intermittent Porphyria: Biochemical and Pathologic Studies of the Explanted Liver

Precursor/porphyrin

Controls (n = 5)

AIP (n = 1)

Fold-change over controls

ALA

20 ± 4.6

58 ± 5.1

2.9

PBG

2.5 ± 1.7

4,442 ± 162

1,777

URO I

12 ± 6.6

38

3.2

URO III

ND

20

—

COPRO I

8.1 ± 13

24

3.0

COPRO III

0.7 ± 1.1

ND

—

PROTO IX

13 ± 12

11

0.8

  1. Data are means ± SDs. Only means are provided for porphyrin levels in AIP liver. ND, not detectable. Porphyrin precursor and porphyrin concentrations are expressed as pmol/mg protein and pmol/g tissue, respectively.
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Molecular Medicine

ISSN: 1528-3658